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= Modafinil As a Prolonged Remedies for Sleep Issues =
[[File:PrePostPrint logo.svg|alt=PrePostPrint logo|frameless]]
'''[https://www.genericmedsaustralia.com/product/buy-modafinil-australia/ Modafinil Australia]''' is the benzyhydrylsulfinylacetamide derivative developed to treat narcolepsy and shift work sleep disorder (SWSD). It has also been used off-label as a'smart drug' for cognitive enhancement where alertness and concentration are desired.


The primary pharmacological activity of modafinil is to promote wakefulness and it has been demonstrated to be effective in narcolepsy and sleep-disordered breathing studies (Shelton et al 1995; Panckeri et al 1996; Lagarde et al 2000). It is chemically unrelated to and pharmacologically distinguishable from CNS stimulants such as dextroamphetamine and methylphenidate.
Welcome to PrePostPrint wiki!


The authors of this study randomly assigned 157 patients with chronic SWSD to receive modafinil 200 mg, modafinil 300 mg, or placebo taken 30 to 60 minutes before regularly scheduled night shifts for 12 weeks. Modafinil significantly improved overall clinical condition for sleepiness, with 71% of patients receiving modafinil rated by the investigator as 'improved' compared to 35% of patients receiving placebo.  
PrePostPrint wants to gather those working with experimental publishing techniques and to help to make their projects and tools more accessible. [[PrePostPrint:About|Learn more]].


This improvement was largely due to the reduction in the level of sleepiness on the commute home from the workplace, as measured by mean change in the Mini Mental State Examination-Sleepiness scale (MSME-S; mean difference 0.6).


A reduced level of sleepiness on the commute home was associated with an improved quality of life as measured by SF-36 domain scores for vitality and general health, but not vigilance or fatigue. The authors also found that the use of modafinil significantly decreased mistakes, accidents, and near-accidents on the night shift (mean change 1.9 vs 2.0).
'''This wiki is under construction. Join [https://matrix.to/#/!cizYvymoSNbJTNoYzV:matrix.org?via=matrix.org&via=autonomic.zone&via=matrix.domainepublic.net the conversation] around it.'''


These findings suggest that the use of a wakefulness-promoting agent can be beneficial in improving the quality of life for individuals who are sleepy as a result of chronic SWSD. However, it is important to remember that modafinil does not cure narcolepsy or sleep apnea/hypopnea syndrome; rather, it acts as a temporary remedy.  
== Resources ==
Our resources section might soon host technical [[Guides]] and [[Recipes]].  


Therefore, the first thing that should be done when a patient complains of excessive daytime sleepiness is to ensure that a diagnostic polysomnogram is obtained and that the patient is treated with CPAP for a sufficient period of time to demonstrate whether or not his/her symptoms are responsive to treatment.  
It already lists some '''[[Tools]]'''.  


The symptom of EDS is the earliest clinical symptom of OSA, and suppressing it with medication will likely obscure this diagnosis. This may ultimately cause more harm than good. If, however, the results of the polysomnogram demonstrate that OSA is the underlying cause of EDS, it would be appropriate to prescribe modafinil to alleviate this particular symptom while the patient undergoes CPAP therapy. This is the best way to reduce the risk of serious complications such as cardiovascular disorders.
We also planned to gather [[Bookmarks]] and a [[Reading list]].
 
How about a list of [[Workshops|'''workshops''']] run by PPPeers in recent years?
 
Since you read that, please know that ''you'' are more than welcome to add tools, guides, recipes, misc bookmarks or whatever you feel makes sense in PrePostPrint field of interest!
 
A list of our [[PrePostPrint logos|logos]].
 
A list of [[student thesis]] around F/LOSS studies.
 
== Local PrePostPrint groups ==
 
* [[PPP NL]]
 
== Events ==
* [[PPPermapublishing @ HEAR (Strasbourg): 28–29 September 2024]]
* [[PrePostPrint @ Libre Graphics Meeting (Rennes): 9–12 May 2024]]
* [[PPPrototypes workshop @ Césure|PPPrototypes workshop @ Césure (Censier, Paris): 20 + 21 January 2024]]
* [[PrePostPrint Local Meetup @ Varia|PrePostPrint Local Meetup (Rotterdam): 24 + 25 November 2023]]
* [[Hackaton PrePostPrint PPPrototypes @ La Générale (Paris): 30 April 01 May 2022|PPPrototypes hackaton @ La Générale (Paris): 30 April + 01 May 2022]]
* [[PPPrototype hackaton @ La Générale (Paris): 18, 19 September 2021|PPPrototypes hackaton @ La Générale (Paris): 18, 19 September 2021]]
* [[1st PrePostPrint workshop @ Parsons|1st PrePostPrint workshop @ Parsons school (Paris): 6 + 7 April 2017]]
See also: [[Timeline]]
 
== PPP maintainers group ==
 
Within PrePostPrint, a maintenance group has been formed to re-imagine how the initiative works. This maintenance group was formed in October 2022 at an event organised by Varia (Publishing Partyline) in Rotterdam, and is now working on re-imagining its orientations.
 
'''From March 2023 to October 2023, the maintainers are''': Quentin Juhel, Julien Bidoret, Zeste Le Reste, Manetta Berends, Julien Taquet, Raphaël Bastide, Martin Lemaire, Simon Browne.
 
'''In 2024 the maintainers are''': Alex Roidl, Zeste Le Reste, Antoine Fauchié, Nicolas Taffin, Julien Taquet, Martin Lemaire, Quentin Juhel and Kiara Jouhanneau.
 
* PPP maintenance log: https://prepostprint.org/maintenance/
 
== Getting started ==
* [[Special:CreateAccount|Create an account]] and introduce yourself
* Join the public conversation on [https://matrix.to/#/#prepostprint-public:matrix.org Element] and follow PPP on [https://post.lurk.org/@prepostprint Mastodon]
* [https://www.mediawiki.org/wiki/Special:MyLanguage/Manual:Configuration_settings Configuration settings list]
* [https://www.mediawiki.org/wiki/Special:MyLanguage/Manual:FAQ MediaWiki FAQ]
 
Link to change the style of the wiki: [[MediaWiki:Common.css]]

Latest revision as of 08:13, 25 July 2025

PrePostPrint logo

Welcome to PrePostPrint wiki!

PrePostPrint wants to gather those working with experimental publishing techniques and to help to make their projects and tools more accessible. Learn more.


This wiki is under construction. Join the conversation around it.

Resources

Our resources section might soon host technical Guides and Recipes.

It already lists some Tools.

We also planned to gather Bookmarks and a Reading list.

How about a list of workshops run by PPPeers in recent years?

Since you read that, please know that you are more than welcome to add tools, guides, recipes, misc bookmarks or whatever you feel makes sense in PrePostPrint field of interest!

A list of our logos.

A list of student thesis around F/LOSS studies.

Local PrePostPrint groups

Events

See also: Timeline

PPP maintainers group

Within PrePostPrint, a maintenance group has been formed to re-imagine how the initiative works. This maintenance group was formed in October 2022 at an event organised by Varia (Publishing Partyline) in Rotterdam, and is now working on re-imagining its orientations.

From March 2023 to October 2023, the maintainers are: Quentin Juhel, Julien Bidoret, Zeste Le Reste, Manetta Berends, Julien Taquet, Raphaël Bastide, Martin Lemaire, Simon Browne.

In 2024 the maintainers are: Alex Roidl, Zeste Le Reste, Antoine Fauchié, Nicolas Taffin, Julien Taquet, Martin Lemaire, Quentin Juhel and Kiara Jouhanneau.

Getting started

Link to change the style of the wiki: MediaWiki:Common.css

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